|
KMID : 0369819730030040428
|
|
Jorunal of Korean Pharmaceutical Sciences
1973 Volume.3 No. 4 p.428 ~ p.438
|
|
|
Stop - flow Analysis of Urinary Excretion of Sulfadiazine in the Dog
|
|
고석태/Ko ST
이돈일/김성오/김재완/Lee DY/Kim SO/Kim JW
|
|
|
Abstract
|
|
|
|
The mechanism of urinary excretion of sulfadiazine was investigated in the dogs by means of stop-flow technique Results of experiments were summarized as follows; 1. The ratios of U/P sulfadiazine to U/P creatinine $(U/P_{SD}:U/P_{cr})$ 수식 이미지 were always lower than 1 in all nephrons, showed a minimum in the proximal area. 2. $U/P_{SD}:U/P_{cr}$ 수식 이미지 were not affected by Probenecid or 2.4-DNP, whereas increased significantly by administration of sodium bicarbonate. 3. Probenecid did not alter the stop-flow patterns in alkalotic dog too. 4. $C_{SD}$ 수식 이미지 (clearance of sulfadiazine ) was appreciably influenced by change in urinary PH, or flow rate. All evidences lead to the conclusion that sulfadiazine reabsorption is passively transported by proximal tubules. No clue for active process, either secretory or reabsorptive, was obtained.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|